This presentation is on environmental toxins and health by Dr. Walter J Crinnion, Environmental Health Specialist. Slidecast not loading? Watch it on slideshare.net
Toxicity is a growing concern for both doctors and their patients.
As more and more toxic chemicals are used in products that increase the "convenience factor" of our busy lives, there have been staggering increases worldwide in diseases such as:
- cancers
- childhood cancers like leukemia
- asthma
- obesity
- autism
- ADD/ADHD
- and chemical sensitivity.
Toxins impact the immune, nervous, and endocrine systems, and unfortunately are passed down to future generations.
Toxic metals and other chemicals often disrupt the methylation pathway and inhibit the production of these important antioxidants: cysteine, glutathione, and metallothionein.
Metametrix provides a variety of tests that reveal a person's toxic burden. Clinicians and patients find these useful for treatment planning and achieving wellness.
The Chlorinated Pesticides profile measures the body burden of chlorinated pesticides, such as DDT. These chemicals are bioaccumulative and can be ingested through fruits, vegetables, and drinking water.
Compounds measured:
- Hexachlorobenzene (HCB)
- Heptachlor Epoxide
- Oxychlordane
- trans-Nonachlor
- DDE (p,p1)
- DDT (p,p1)
- Dieldrin
- Mirex
The PCBs profile measures the body burden of polychlorinated biphenyls (PCBs). PCBs are bioaccumulative and found in food sources such as fish, fatty meats, and dairy products.
Compounds measured:
Dioxin-like Polychlorinated Biphenyls:
- 2,3',4,4',5-Pentachlorobiphenyl
- 3,3',4,4',5-Pentachlorobiphenyl
- 3,3',4,4',5,5'-Hexachlorobiphenyl
Non-dioxin-like Polychlorinated Biphenyls:
- 2,2',3,4,4',5'-Hexachlorobiphenyl
- 2,2',4,4',5,5'-Hexachlorobiphenyl
- 2,2',3,4,4',5,5'-Heptachlorobiphenyl
The Volatile Solvents profile determines volatile solvents exposure. Volatile solvents are mostly inhaled from products such as furniture, building materials, cleaning agents, and inks.
Compounds measured:
- Benzene
- Ethylbenzene
- m,p-Xylene
- o-Xylene
- Styrene
- Toulene
- Hexane
- 2-methylpentane
- 3-methylpentane
Proper porphyrin production is essential for our body's capacity to detoxify toxins. The Porphyrins profile can help identify the severity of heavy metal toxicity or organic chemical exposure in patients.
Compounds measured:
- Uroporphyrin I and III
- Heptacarboxyporphyrinogen
- Hexacarboxyporphyrinogen
- Pentacarboxyporphyrinogen
- Precoproporphyrin
- Coproporphyrinogen I
- Coproporphyrinogen III
The Toxic Metals profile focuses on five highly toxic heavy metals and is available with whole blood or urine specimen types.
Compounds measured:
- Arsenic
- Cadmium
- Lead
- Mercury
- Aluminum
The Phthalates & Parabens Profile helps determine body burdens of these chemicals from everyday exposures. Phthalates are plasticizers used to make PVC plastics more flexible. Parabens keep fungus and mold from personal care products such as shampoos, lotions, soaps, gels, and more.
Compounds measured:
- mono-ethyl phthalate (MEtP)
- mono-2-ethylhexyl phthalate (MEHP)
- mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
- mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP)
- methylparaben
- ethylparaben
- propylparaben
- butylparaben

Additional Resources:
"Blood levels of chlorinated pesticides, toxic aromatics and aliphatic volatile organic chemicals, herbicides, and measurement of other solvents are tremendously useful in determining whether a chemical overload has occurred." -William J. Rea, Chemical Sensitivity: Volume IV, pg. 2105
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