Found in leafy green vegetables, natural folates are the group name for related members of this B-vitamin family. A synthetic form, folic acid (FA), is used in fortified foods and most dietary supplements. In fact, looking to combat birth defects such as cleft palates and spina bifida, the U.S. government began mandating the use of synthetic FA to fortify the national food supply in 1988. However, new research indicates that the increased intake of synthetic FA, combined with the slow and variable effects produced by the enzyme Dihydrofolate Reductase (DHFR), can lead to an accumulation of Unmetabolized Folic Acid (UMFA) in the blood.
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