DNA/Oxidative Stress Marker - Urine

The interaction of reactive oxygen species with DNA and RNA produces oxidation products of these base rings. DNA repair enzymes must remove the damaged bases in order to maintain viability. Oxidation of guanosine produces 8-hydroxy-2'-deoxyguanosine (8OHdG). The concentration of 8OHdG in urine has been shown to be an accurate measure of the rate of polynucleotide oxidative damage. Elevated 8OHdG is a sign that antioxidant nutrient intake may need to be increased. Toxicants and lifestyle stress factors may contribute to increased oxidative challenge.

Test name(s)

0087 - 8-Hydroxy-2'-deoxyguanosine*

Description

Oxidation of guanosine produces 8-hydroxy-2'-deoxyguanosine (8OHdG). The concentration of 8OHdG in urine has been shown to be an accurate measure of the rate of polynucleotide oxidative damage. Elevated 8OHdG is a sign that antioxidant nutrient intake may need to be increased. Toxicants and lifestyle stress factors may contribute to increased oxidative challenge.

Method

LC/MS-MS, Spectrophotometry

Turnaround time

6-8 days, 7 days average

Analytes

8-Hydroxy-2'-deoxyguanosine*
Creatinine

*Not available in New York

Specimen Collection Instructions

• Organix-KI.pdf

Sample Reports Example of how test results will be reported, including reference ranges and graphs indicating high and low percentiles of each analyte.

• DNA-Oxidative-Stress-SR.pdf

Patient Briefs

• Oxidative-Stress-PB.pdf

If you do not have the free Adobe Acrobat Reader, download it here.

Books

• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Presentations

• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.
• Evaluating Oxidative Stress in Chronic Degenerative Conditions: From Autism to Aging - Oxidative stress markers are discussed. Oxidative stress is explained and four cases are presented.
• Evaluating B Vitamin Status in Autism - The B vitamin markers of the Organix test are discussed and their relation to autism. Two autism cases are also discussed.

References

• DNA/Oxidative Stress Marker References