Organix Basic Profile - Urine

The Organix Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions to help maximize patient responses and lead to improved patient outcomes.

Advantages of the Organix Basic Profile

• Innovative Method - The LC/MS-MS method, which is also used to screen newborns for metabolic disorders, requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.
• Single Urine Specimen - A single overnight urine collection is easy for patients, leading to increased patient compliance.
• Follow-up Testing Option - The Organix Basic offers an easy and affordable follow-up testing option to monitor targeted therapy in patients when dysbiosis markers are unneeded.

Why use an organic acids test?

Organic acids are metabolic intermediates produced in pathways of central energy production, detoxification, neurotransmitter breakdown, and intestinal microbial activity. Accumulation of specific organic acids in urine often signals a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. An organic acids urine test helps reveal activity and changes at the metabolic level, helping practitioners discover hidden issues and pinpoint where therapeutic focus is needed.

From a single urine specimen, the Organix Basic Profile provides important information in the areas of:

• Vitamin and mineral insufficiencies
• Amino acid insufficiencies like carnitine and N-acetyl cysteine (NAC)
• Oxidative damage and antioxidant sufficiency markers
• Indicators to assess detoxification sufficiency
• The best functional markers of B-complex deficiency
• Neurotransmitter metabolites to assess central nervous system (CNS) function
• Mitochondrial energy production assessment via citric acid cycle components
• Methylation sufficiency status
• Lipoic acid and CoQ10 sufficiency markers

The Organix Profiles can provide important information for treating certain conditions, including:

Test name(s)

0291 - Organix Basic Profile
3291 - Organix Basic Profile NY

Description

The Organix Basic Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.

Method

LC/MS-MS Tandem Mass Spectrometry

Turnaround time

8-14 days, 12 days average

Analytes

FATTY ACID METABOLISM
Adipate
Suberate
Ethylmalonate

CARBOHYDRATE METABOLISM
Pyruvate
L-Lactate*
Beta-Hydroxybutyrate

ENERGY PRODUCTION (CITRIC ACID CYCLE)
Citrate
cis-Aconitate
Isocitrate
Alpha-Ketoglutarate
Succinate
Fumarate
Malate
Hydroxymethylglutarate

B-COMPLEX VITAMIN MARKERS
Alpha-Ketoisovalerate
Alpha-Ketoisocaproate
Alpha-Keto-Beta-Methylvalerate
Xanthurenate
Beta-Hydroxyisovalerate

METHYLATION COFACTOR MARKERS
Methylmalonate
Formiminoglutamate

NEUROTRANSMITTER METABOLISM MARKERS
Vanilmandelate
Homvanillate
5-hydroxyindoleacetate
Kynurenate
Quinolinate
Picolinate*

DETOXIFICATON INDICATORS
2-Methylhippurate
Orotate
Glucarate
Alpha-Hydroxybutyrate
Pyroglutamate

Creatinine

*Not available in New York

Specimen Collection Instructions

• Organix-KI.pdf

Sample Reports Example of how test results will be reported, including reference ranges and graphs indicating high and low percentiles of each analyte.

• Organix-Basic-SR.pdf

Interpretive Guides Information on individual analytes and possible patterns that may be indicated on your test results. Further supplement recommendations, diet modifications, and other treatment options may also be included to help guide your treatment.

• Organix-Basic-IG.pdf

Patient Briefs

• Organix-PB.pdf

If you do not have the free Adobe Acrobat Reader, download it here.

Articles

• What Are Organic Acids? - Organic acids are products of metabolism that can sensitively identify nutrient deficiencies that lead to metabolic roadblocks.
• Important Markers of Neurological Inflammation: Kynurenate & Quinolinate - The kynurenine (KYN) pathway is a major route of L-tryptophan catabolism and operates as a mechanism of defense against intracellular pathogens and as a mediator of stress response signals to the brain.
• Mitochondrial Dysfunction and Disease - This article examines the structure and function of mitochondria, details the mechanisms by which acquired mitochondrial dysfunction can create a wide range of symptoms and provides a rational approach to treatment.
• Assessment of Biochemical and Nutritional Individuality through Organic Acid Testing - Organic acid testing provides a broad view of many important bodily functions amenable to nutritional interventions. One urine sample can be used to evaluate dysbiosis, detoxification, and nervous system transmitter balance as well as multiple nutrient deficiencies.
• Autistic Therapies Focused by Laboratory Data - This review focuses on laboratory evaluation of organic acidurias for revealing metabolic weaknesses in autism that may be responsive to aggressive nutritional, detoxification and gastrointestinal immune balancing interventions.

Books

• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Metabolic Pathways

• Citric Acid Cycle - Markers of Coenzyme Q10 Synthesis and Function Elevation of organic acids in urine can reveal inhibition of the coenzyme Q10 biosynthetic pathway (A) or interruptions of the electron transport system (B) from inability to sustain adequate CoQ10 levels in the inner mitochondrial membrane.

Presentations

• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.
• Functional Nutritional Assessment Using Organic Acid Analysis - Dr. Bralley briefly discusses what organic acids are and the importance of organic acid analysis. Additionally, Dr. Bralley discusses how they can play a key role in improving patient's health in a clinical practice.
• Evaluating the Complex Patient with Organix Testing - Four cases are presented in this teleconference: an autistic child, a child with mitochondrial myopathy, an adult with depression and a professional athlete. Aspects of their organic acid tests are focused on.
• From Simple Headaches to Cancer: Assessing the Role of Toxic Burden in Disease - The detoxification markers of the Organix profile are discussed, along with five cases.
• Evaluating B Vitamin Status in Autism - The B vitamin markers of the Organix test are discussed and their relation to autism. Two autism cases are also discussed.
• Evaluating Neurotransmitter Status in Neuropsychological and Physiological Complaints - Neurotransmitter markers in the Organix test are discussed along with five cases.
• Evaluating Mitochondrial Function and Disease: Managing the Fatigued Patient - The mitochondrial function markers of the Organix test are discussed. Deficiency markers are explained, as well as the supplements used to correct the deficiencies.
• Wellness Hour - Dr. Bralley Interview - Dr. J. Alexander Bralley participates in an interview with Randy Alvarez of The Wellness Hour, the leader in health news and information. This interview takes place at the 2005 IFM International Symposium in California. View this video from Dr. Bralley as he discusses who Metametrix is and the testing services provided.

References

• Organix References