Women's Health Profile - Blood & Urine

Understanding your health is necessary for optimal living. As with most other disease states, preventative care and the ability to predict what we are at risk for at the earliest stages is ideal in treating each individual.

The Women's Health Profile can help assess those risk factors associated with genetics, biochemical imbalances, and environmental influences for women of all ages.

A Profile for Female Patients Concerned About:

• Metabolic Syndrome: Tests markers related to central obesity, raised blood pressure, dyslipidemia, insulin resistance, and ADMA.
• ADMA (asymmetric dimethylarginine): Regulates rates of nitric oxide (NO) formation. Nitric oxide acts as a signal molecule in the nervous system, as a weapon against infections, as a regulator of blood pressure, and as a gate keeper of blood flow to the organs.
• Serum Lipid Peroxides: A cardiovascular marker that monitors the tissue damaging effects of oxidative stress.
• Organix: Establish a nutritional and metabolic basis for supplementation.
• Estronex: Measures estrogen metabolites and the ratios of "good" and "bad" estrogens. Modifying these ratios may reduce the risk of estrogen-sensitive cancers, including breast cancer.
• Fatty Acids: Measures omega-3 and omega-6 fatty acids and calculates key indicators, such as AA/EPA ratio, to establish your optimal balance.

The Path to Optimal Health, Ideal Living, and Maintaining Youth

• Endocrine and Insulin Sensitivity
• Estrogen Metabolites
• Cell Regulation: Nitric Oxide Regulation and Eicosanoid Balance
• Cell Protection: Cell Membrane Oxidation and Elemental Cofactor Status
• Metabolic and Nutrient Markers: B Vitamin Insufficiency, Cellular Energy, Neural Function, and Detoxification

Test name(s)

4146 - Women's Health Profile*

Description

The Women’s Health Profile is a combination of tests specifically designed for women. The Women’s Health Profile measures organic acids, fatty acids, serum lipid peroxides, ADMA, markers of metabolic syndrome, and estrogen. It can also help assess risk factors associated with genetics, biochemical imbalances, and environmental influences.

Method

EIA, Spectrophotometry, LC/MS/MS, HPLC, GC/MS, Automated Chemistry, Chemiluminescence, Colorimetric

Turnaround time

13-15 days, 14 days average

Analytes

ESTROGEN METABOLISM
2-Hydroxyestrogens (2-OHE) - Sum of 2-Hydroxyestrone (2-OHE1) and 2-Hydroxyestradiol (2-OHE2)
4-hydroxyestrone (4-OHE1)
16α-hydroxyestrone (16α-OHE1)
2-methoxyestrone (2-OMeE1)
4-methoxyestrone (4-OMeE1)
Creatinine

ESTROGEN METABOLISM - Ratios
2-OHE:16α-OHE1
2-OHE1:2-OMeE1

FATTY ACID METABOLISM
Adipate
Ethylmalonate
Suberate

CARBOHYDRATE METABOLISM
β-Hydroxybutyrate
Pyruvate

ENERGY PRODUCTION (CITRIC ACID CYCLE)
α-Ketoglutarate
Citrate
Cis-Aconitate
Isocitrate
Succinate
Fumarate
Malate
Hydroxymethylglutarate

B-COMPLEX VITAMIN MARKERS
α-ketoisovalerate
α-keto-β-Methylvalerate
α-ketoisocaproate
Xanthurenate
β-Hydroxyisovalerate

METHYLATION COFACTOR MARKERS
Methylmalonate
Formiminoglutamate

NEUROTRANSMITTER METABOLISM MARKERS
Vanilmandelate
Homovanillate
5-Hydroxyindoleacetate
Kynurenate
Quinolinate

DETOXIFICATION INDICATORS
2-Methylhippurate
Orotate
Glucarate
α-Hydroxybutyrate
Pyroglutamate

INSULIN SENSITIVITY
HDL Cholesterol
LDL Cholesterol
Triglycerides
Glucose
Insulin

NITRIC OXIDE REGULATION
ADMA
Arginine
Arginine/ADMA ratio

EICOSANOID BALANCE
Eicosapentaenoic
Docosahexaenoic
Arachidonic
AA/EPA ratio

CELL MEMBRANE OXIDATION
Lipid Peroxides

ELEMENTAL COFACTOR STATUS
Magnesium
Zinc

*Not available in New York

Specimen Collection Instructions

• Womens-Health-KI.pdf

Sample Reports Example of how test results will be reported, including reference ranges and graphs indicating high and low percentiles of each analyte.

• Womens-Health-SR.pdf

Interpretive Guides Information on individual analytes and possible patterns that may be indicated on your test results. Further supplement recommendations, diet modifications, and other treatment options may also be included to help guide your treatment.

• Womens-Health-IG.pdf

Patient Briefs

• Womens-Health-PB.pdf

If you do not have the free Adobe Acrobat Reader, download it here.

Articles

• Assessment of Biochemical and Nutritional Individuality through Organic Acid Testing - Organic acid testing provides a broad view of many important bodily functions amenable to nutritional interventions. One urine sample can be used to evaluate dysbiosis, detoxification, and nervous system transmitter balance as well as multiple nutrient deficiencies.

Books

• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Case Studies

• 8-Year Multiple Sensitivity, Oxidative Stress - Multiple abnormalities in a woman with multiple sensitivities.
• Probiotic Sensitivity - Profound elevation of 5-HIA suggest a bowel-specific serotonin syndrome that is producing a hypersensitivity to changes in the bacterial colonies of the gut.
• 8-Year Pizza-Yeast Connection - Case of severe yeast overgrowth due to overconsumption of high carbohydrate food.
• Fungal Overgrowth but not Invasive Candidiasis - This case is of a 46 year old female who was overweight and poor muscle tone. She presented herself originally for severe headaches of a chronic nature. They improved with pressure and with the use of prednisone. This issue began at age 25.
• Congenital Hypotonia - Evidence of profound mitochondrial oxidation lesions are seen in this infant with breathing difficulties.
• Dysbiosis from Corticosteroid Use - The common assumption that prolonged courses of corticosteroid treatment can precipitate Candida yeast infections have never been so evident as in this case.
• Biotin & Detoxification Needs in Cognitively Delayed Adult - Biotin deficiency may be linked to hyperlipidemia and up-regulated fatty acid desaturation in this mildly psychotic man.
• Breast Cancer Risk Reduction- Increased 2/16 OH Ratio - A series of 5 tests over a year show how a young woman can detect her estrogen metabolic status and make dietary modifications to affect reduction of cancer risk.
• Yeast - Nitric Oxide Pattern - A possible case of autism and several metabolic markers that can be improved.
• Prader-Willi-2 - Mitochondrial distress with oxidative stress and extreme glutathione up-regulation is exacerbated by glycine conjugation insufficiency and intestinal bacterial overgrowth.
• Prader-Willi 1 - A series of Organix reports shows the nature of this genetic abnormality as numerous, severe, and persistent metabolic disturbances.
• Philadelphia Chromosome - When follow up testing looks much worse while a young leukemia patient is improving, multiple factors are at play. Underlying dysbiosis and glutathione issues are involved in this case.
• D-Lactate Study Set - Seven cases illustrate a variety of other bacterial marker abnormalities when D-lactate is high. The patterns instruct about etiologies and intervention strategies.
• High Amino Developmental Delay - A combination of environmental, nutritional, and genetic metabolic weaknesses were found as potential causative factors in the failure of neurological development for this 2 year-old girl. Vitamin B6 insufficiency, arsenic exposure, and intestinal dysbiosis are key features in the initial laboratory workup.

Presentations

• Building the Organix Profile Into Clinical Practice - An educational module for users of the Metametrix Urinary Organic Acid (Organix) Profile. Covers the 7 steps of an Organix evaluation.
• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.
• Estrogen and Breast Cancer - Dr. Kara Fitzgerald and Cass Nelson-Dooley discuss estrogen and lowering breast cancer risk in an hour long teleconference.
• Evaluating the Complex Patient with Organix Testing - Four cases are presented in this teleconference: an autistic child, a child with mitochondrial myopathy, an adult with depression and a professional athlete. Aspects of their organic acid tests are focused on.
• Patching the Leaky Gut: Evaluating Intestinal Microbial Burden using Organic Acids - Four cases using Organix testing: Lyme disease, regressive autism, chronic fatigue/fibromyalgia syndrome, Melnick-Needle
• From Simple Headaches to Cancer: Assessing the Role of Toxic Burden in Disease - The detoxification markers of the Organix profile are discussed, along with five cases.
• Evaluating Oxidative Stress in Chronic Degenerative Conditions: From Autism to Aging - Oxidative stress markers are discussed. Oxidative stress is explained and four cases are presented.
• Evaluating B Vitamin Status in Autism - The B vitamin markers of the Organix test are discussed and their relation to autism. Two autism cases are also discussed.
• Evaluating Neurotransmitter Status in Neuropsychological and Physiological Complaints - Neurotransmitter markers in the Organix test are discussed along with five cases.
• Evaluating Mitochondrial Function and Disease: Managing the Fatigued Patient - The mitochondrial function markers of the Organix test are discussed. Deficiency markers are explained, as well as the supplements used to correct the deficiencies.