TRIAD Profile - Blood & Urine

The TRIAD Profile helps you target each patient's specific needs by integrating three powerful profiles—Organix, Amino Acids, and Allergix IgG Food Antibodies—into a single innovative tool offering customized intervention options.

Patients with similar symptoms can have remarkably different metabolic and nutritional needs. And patients with comparable laboratory results often exhibit widely divergent symptoms.

Three Integrated Profiles = One Fully Customized Solution

The logic behind the TRIAD Profile is simple. Clinicians, like you, told us that interventions based on Organix, Amino Acid, or Allergix IgG Food Antibodies testing produced excellent results. The TRIAD Profile uses the synergetic power of these three components to produce better results, faster. Because targeted, customized interventions based on the TRIAD Profile can be more cost effective than simple protocol-based treatment plans, the TRIAD Profile represents real value.

Only the TRIAD Profile includes fully customized intervention guidelines—custom vitamin/mineral formulas, custom amino acid blends, and a customized food rotation diet—so you can focus your interventions on the specific needs of each patient.

The TRIAD Profile allows simultaneous assessment of:

• Vitamin and mineral sufficiency
• Insufficiencies of carnitine and NAC
• Oxidative stress and antioxidant sufficiency
• Detoxification adequacy
• Functional status of B-vitamins
• Neurotransmitter metabolism
• Mitochondrial energy production
• Methylation sufficiency status
• Lipoic acid and CoQ10 sufficiency
• Specific markers of bacterial and yeast dysbiosis
• Essential amino acids sufficiency
• Food sensitivities
• Intestinal hyperpermeability

Test name(s)

0400 - TRIAD™ Profile

Description

This profile is a combination of the Allergix IgG4 Food Antibodies Assay (0075), Organix Comprehensive (0091) and Amino Acid Plasma-20 (0011) profiles. The Triad Profile allows simultaneous assessment of food sensitivities and intestinal hyperpermeability; urinary microbial metabolites, detoxification indicators, neural function markers, and functional vitamin and mineral sufficiency markers; and essential amino acid status. The Triad Profile provides the clinician with a powerful array of clinical tools to design appropriate therapeutic interventions for the patient.

Method

LC/MS-MS, HPLC, Spectrophotometry, EIA

Turnaround time

13-15 days, 14 days average

Analytes

All analytes from the following profiles:
0011 Amino Acids 20 - Plasma
0091 Organic Acids - Urine
0075 IgG4 Food Antibodies - 90 Antigens - Serum

Specimen Collection Instructions

• TRIAD-KI.pdf

Sample Reports Example of how test results will be reported, including reference ranges and graphs indicating high and low percentiles of each analyte.

• TRIAD-SR.pdf

Interpretive Guides Information on individual analytes and possible patterns that may be indicated on your test results. Further supplement recommendations, diet modifications, and other treatment options may also be included to help guide your treatment.

• TRIAD-IG.pdf
• Allergix-IG.pdf

Patient Briefs

• TRIAD-PB.pdf

Additional Downloads

• Allergix 4-Day Rotation Diet

If you do not have the free Adobe Acrobat Reader, download it here.

Articles

• What Are Organic Acids? - Organic acids are products of metabolism that can sensitively identify nutrient deficiencies that lead to metabolic roadblocks.
• Why Test for Coenzyme Q10? - This article illustrates that measuring both direct and indirect biomarkers of CoQ10 sufficiency in order to appropriately diagnose and treat patients, and to monitor CoQ10 administration, can markedly improve patient outcomes and prevent mitochondrial related disease.
• Assessment of Biochemical and Nutritional Individuality through Organic Acid Testing - Organic acid testing provides a broad view of many important bodily functions amenable to nutritional interventions. One urine sample can be used to evaluate dysbiosis, detoxification, and nervous system transmitter balance as well as multiple nutrient deficiencies.
• Significance of Urinary Tartaric Acid - Letter to the editor of Clinical Chemistry supporting the claim that urinary tartaric acid is not a valid measure of yeast overgrowth.
• Autistic Therapies Focused by Laboratory Data - This review focuses on laboratory evaluation of organic acidurias for revealing metabolic weaknesses in autism that may be responsive to aggressive nutritional, detoxification and gastrointestinal immune balancing interventions.
• Urinary Markers of Intestinal Yeast - Letter to the editor of Towsend Letter for Doctors and Patients gives the argument against the use of urinary arabinose for detection of invasive candidiasis and for the use of urinary D-arabinitol instead.
• Urinary Markers of Yeast Overgrowth - This paper presents a review of scientific reports of some urinary markers of yeast overgrowth.

Books

• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Case Studies

• The TRIAD Profile in Depression and Migraine Headache: A Case Study - Standard medical treatments for major depressive disorder and migraine headache are only partially effective. Clinical improvement requires correction of underlying metabolic difficulties. This case illustrates the power of multiple markers to focus on key metabolic issues.
• 8-Year Multiple Sensitivity, Oxidative Stress - Multiple abnormalities in a woman with multiple sensitivities.
• Probiotic Sensitivity - Profound elevation of 5-HIA suggest a bowel-specific serotonin syndrome that is producing a hypersensitivity to changes in the bacterial colonies of the gut.
• 8-Year Pizza-Yeast Connection - Case of severe yeast overgrowth due to overconsumption of high carbohydrate food.
• Fungal Overgrowth but not Invasive Candidiasis - This case is of a 46 year old female who was overweight and poor muscle tone. She presented herself originally for severe headaches of a chronic nature. They improved with pressure and with the use of prednisone. This issue began at age 25.
• Congenital Hypotonia - Evidence of profound mitochondrial oxidation lesions are seen in this infant with breathing difficulties.
• Dysbiosis from Corticosteroid Use - The common assumption that prolonged courses of corticosteroid treatment can precipitate Candida yeast infections have never been so evident as in this case.
• Biotin & Detoxification Needs in Cognitively Delayed Adult - Biotin deficiency may be linked to hyperlipidemia and up-regulated fatty acid desaturation in this mildly psychotic man.
• Yeast - Nitric Oxide Pattern - A possible case of autism and several metabolic markers that can be improved.
• Prader-Willi-2 - Mitochondrial distress with oxidative stress and extreme glutathione up-regulation is exacerbated by glycine conjugation insufficiency and intestinal bacterial overgrowth.
• Prader-Willi 1 - A series of Organix reports shows the nature of this genetic abnormality as numerous, severe, and persistent metabolic disturbances.
• Philadelphia Chromosome - When follow up testing looks much worse while a young leukemia patient is improving, multiple factors are at play. Underlying dysbiosis and glutathione issues are involved in this case.
• D-Lactate Study Set - Seven cases illustrate a variety of other bacterial marker abnormalities when D-lactate is high. The patterns instruct about etiologies and intervention strategies.
• High Amino Developmental Delay - A combination of environmental, nutritional, and genetic metabolic weaknesses were found as potential causative factors in the failure of neurological development for this 2 year-old girl. Vitamin B6 insufficiency, arsenic exposure, and intestinal dysbiosis are key features in the initial laboratory workup.

Presentations

• Why Test for Amino Acids? - The Amino Acid Plasma 20 test is reviewed by Dr. Redmond. Each category is explained and the reasons for highs and lows are discussed.
• Building the Organix Profile Into Clinical Practice - An educational module for users of the Metametrix Urinary Organic Acid (Organix) Profile. Covers the 7 steps of an Organix evaluation.
• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.
• Evaluating the Complex Patient with Organix Testing - Four cases are presented in this teleconference: an autistic child, a child with mitochondrial myopathy, an adult with depression and a professional athlete. Aspects of their organic acid tests are focused on.
• Patching the Leaky Gut: Evaluating Intestinal Microbial Burden using Organic Acids - Four cases using Organix testing: Lyme disease, regressive autism, chronic fatigue/fibromyalgia syndrome, Melnick-Needle
• From Simple Headaches to Cancer: Assessing the Role of Toxic Burden in Disease - The detoxification markers of the Organix profile are discussed, along with five cases.
• Evaluating Oxidative Stress in Chronic Degenerative Conditions: From Autism to Aging - Oxidative stress markers are discussed. Oxidative stress is explained and four cases are presented.
• Evaluating B Vitamin Status in Autism - The B vitamin markers of the Organix test are discussed and their relation to autism. Two autism cases are also discussed.
• Evaluating Neurotransmitter Status in Neuropsychological and Physiological Complaints - Neurotransmitter markers in the Organix test are discussed along with five cases.
• Evaluating Mitochondrial Function and Disease: Managing the Fatigued Patient - The mitochondrial function markers of the Organix test are discussed. Deficiency markers are explained, as well as the supplements used to correct the deficiencies.