Allergix IgG4 Food Antibodies 90 - Serum

What is an IgG4 response?

IgG4 antibodies are associated with non-atopic or "delayed" food reactions that can worsen or contribute to many different health problems. These reactions are considered the most common form of immunologically mediated food intolerance.

An IgG4 response to food is actually more common than the IgE response, which causes an immediate reaction. IgG4 acts as a blocking antibody, protecting the individual from potentially fatal IgE reactions. These reactions are more difficult to notice since they can occur hours or even days after consumption of an offending food. In some cases, a person's reaction to a food may occur several days after eating the offending food and the link between the food and their symptoms may not be connected. These "hidden" food allergies are caused by increasing blood levels of IgG4 antibodies in reaction to specific foods.

Metametrix Innovation in IgG Antibody Testing

• New patent-pending IgG4 assay allows our test to show less false positives leading to better patient compliance.
• First test to quantitate IgG4
• Eliminates non-specific binding, lowering false positives without rejecting true positives

Common offending foods eaten frequently and hard to avoid:

• Milk
• Corn
• Wheat
• Egg
• Foods processed with molds such as black tea, breads, and fruit juices

Metametrix offers two Allergix IgG4 Food Antibody Profiles:

• IgG4 Food Antibody Profile - measures serum levels of IgG4 antibodies specific to 90 food antigens. A four-day rotation diet is included.
• Bloodspot IgG4 Food Antibody Profile - measures levels of IgG4 antibodies specific to 30 common offending foods from an easy-to-use finger stick.  A four-day rotation diet is included.

Special Pricing is available for the following combination profiles:

• 0270 - IgG4 and IgE Food Antibodies
• 0278 - IgG4 Food Antibodies and Celiac Profile

Test name(s)

0075 - IgG4 Food Antibodies 90 Antigens
0270 - IgG4 and IgE Food Antibodies
0271 - IgG4 and IgE Food Antibodies - NY
0278 - IgG4 Food Antibodies and Celiac Profile

Description

The Allergix IgG4 antibody is related to “delayed” or non-atopic food reactions that exacerbate or contribute to many different health problems. Simultaneous high levels of many IgG4 food-specific antibodies are generally associated with intestinal hyperpermeability. This profile measures the IgG4 levels in serum that react to 90 different foods, including commonly eaten foods such as corn, milk, egg, and wheat. A food reaction patient guide is provided with each test result.

Method

ELISA

Turnaround time

4-7 days, 7 days average

Analytes

Almond
Apple
Apricot
Asparagus
Aspergillus Mold
Avocado
Banana
Barley
Bean, String
Beef
Black Pepper
Blueberry
Broccoli
Cabbage
Cantaloupe
Carrot
Casein
Cashew
Cauliflower
Celery
Chicken
Chocolate
Cinnamon
Clam
Coconut
Codfish
Coffee
Corn
Crab
Cranberry
Cucumber
Egg White
Egg Yolk
Flounder
Garlic
Ginger
Grape
Grapefruit
Halibut
Honeydew
Lamb
Lemon
Lentil
Lettuce
Lima Bean
Lobster
Mackerel
Malt
Milk
Mushroom
Mustard Greens
Navy Bean
Oat
Olive
Onion
Orange
Oyster
Pea, Green
Peach
Peanut
Pear
Pecan
Pepper, Green
Pineapple
Pinto Bean
Pistachio
Pork
Potato
Rice
Rye
Salmon
Sesame
Shrimp
Soybean
Spinach
Strawberry
Sunflower
Sweet Potato
Tea
Tomato
Trout
Tuna
Turkey
Vanilla
Watermelon
Walnut, English
Wheat
Yeast, Baker's
Yeast, Brewer's
Zucchini

Specimen Collection Instructions

• Allergix-KI.pdf

Sample Reports Example of how test results will be reported, including reference ranges and graphs indicating high and low percentiles of each analyte.

• Allergix-IgG4-Food-90-Serum-SR.pdf

Interpretive Guides Information on individual analytes and possible patterns that may be indicated on your test results. Further supplement recommendations, diet modifications, and other treatment options may also be included to help guide your treatment.

• Allergix-IG.pdf

Patient Briefs

• Allergix-PB.pdf

Additional Downloads

• Allergix 4 Day Rotation Diet Form

If you do not have the free Adobe Acrobat Reader, download it here.

Articles

• Understanding IgG4 Food Sensitivities - This article explains IgG4 food sensitivities and their subclasses. It also compares the various types of IgG4 laboratory testing.
• IgE and IgG Immune Reactions to Food - Many people think of allergies exclusively in terms of airborne allergens such as pollen, dust, and molds. However, immune reactions also can result from reactions to foods.

Books

• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Case Studies

• 29-Year-Old Female with Ulcerative Colitis - EM was a 29-year-old female presenting with extremely active ulcerative colitis (UC). Colonoscopy had detected pancolitis. She was at her lowest body weight since adulthood. She had chronic diarrhea and severe fatigue.
• The TRIAD Profile in Depression and Migraine Headache: A Case Study - Standard medical treatments for major depressive disorder and migraine headache are only partially effective. Clinical improvement requires correction of underlying metabolic difficulties. This case illustrates the power of multiple markers to focus on key metabolic issues.

Podcasts

• Gut-Brain Connection: An Inside Look at Depression - During a recent Metametrix sponsored breakfast at the IFM Symposium in Hollywood, Florida, Dr. Todd LePine gave a compelling presentation entitled the Gut-Brain Connection: An Inside Look at Depression.
• Naturopathic Approaches to Pain Patients - In this edition of Clinician’s Corner, Dr. Kara Fitzgerald, ND shares her clinical tools and treatments that have resulted in remarkable improvement for patients who had otherwise given up all hope of getting better.
• Autism and Laboratory Testing - April is the month where many organizations focus on raising awareness of autism, and Metametrix would like to contribute by generating awareness of the laboratory tests that can help to uncover metabolic factors that may be treated in each individual with this complex disease.

Presentations

• Testing and the 7 Keys to an Ultramind - Metametrix helps doctors, like Dr. Mark Hyman, use laboratory tests to identify nutritional and metabolic statuses in the 7 key areas of an UltraMind.
• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.

References

• Allergix IgG4 Food References