The GI Effects Microbial Ecology Profile uses molecular and microscopic approaches for stool-based gastrointestinal diagnostics. O&P technology is the gold standard diagnostic methodology for parasite detection, while PCR technology provides an expansive assessment of anaerobic gut microflora.
The Microbial Ecology Profile
The gut is made up of both aerobic and anaerobic bacteria. While over 95% of the bacteria are anaerobes, aerobic bacteria can reach high densities in the cecum. Under normal homeostatic conditions, the intestinal microflora are of central importance in preventing colonization by pathogens, termed “colonization resistance.” Microorganisms perform a host of useful functions, such as fermenting unused energy substrates, communicating with the immune system, preventing growth of harmful species, regulating the development of the gut, producing vitamins for the host (such as biotin and vitamin K), and producing hormones.
The Microbial Ecology profile focuses on predominate and opportunistic bacteria, as well as yeast/fungi, parasites, adiposity index, and microbial fungi sensitivities. In addition, in patients for whom there is a high clinical index of suspicion for C. difficile, H. pylori, Shiga Toxin E. coli, or Campylobacter spp infection, enzyme immunoassay (EIA) assessment is available as an add-on. The Microbial Ecology Profile is also an easy and cost-effective follow-up testing option to monitor targeted therapy in patients.
Advantages of the GI Effects Stool Profiles
Clinical utility for parasite detection is enhanced with O&P technology, the current clinical diagnostic standard of care. Optimized Parasite Recovery (OPR) is Genova Diagnostics’ version of O&P technology which utilizes a concentration process to optimize parasite detection. Because the vast majority of commensal gut microflora are anaerobes that present culture challenges, microbial DNA analysis is utilized to optimize the assessment of gut microbial composition.
Parasite Recovery Literature suggests that >90% of enteric parasitic infections are detected in a sample from a single stool collection. However, increased recovery results from the collection of additional specimens on separate days. Scientific bodies such as the Centers for Disease Control recommend a minimum of three samples on three separate days to optimize parasite detection when there is a high clinical index of suspicion for parasitic infection. Parasites have been detected in 20-24% of U.S. patients with mild to moderate GI symptoms.
GI Effects 2205: Microbial Ecology Profile* - Bacteria, fungi/yeast, parasites
*Not available in New York
Microscopic Examination, Macroscopic evaluation, EIA, PCR
|20||87798||DNA NOS Amplified Probe|
|1||87177||Parasitology Identification, Concentrate|
|1||87209||Parasitology Identification, Trichome Stain|
|1||87336||Entamoeba histolytica, EIA|
|1||87329||Giardia lamblia, EIA|