High 2-methylhippurate and Low Sulfate

Summary

Xylene exposure found in elevated levels of 2-methylhippurate and low levels of sulfate.

This content was created by the Metametrix Institute

History

Becky, a 32-year-old female, was feeling fine and exhibited no symptoms at her yearly physical.  However, her doctor ordered an Organix Comprehensive Profile  as part of her physical. The clinician found that Becky had elevated levels of 2-methylhippurate and low levels of sulfate.

Age

32

Gender

Female

Description of Results

2-Methylhippurate is a product of petroleum and coal tar. 2-Methylhippurate comes from 2-methylbenzoate which is a glycine conjugation step requiring adequate glycine. Sulfate levels represent sulfur amino acid levels, such as cysteine and methionine. Sulfur amino acids and glycine are needed for glutathione production.

Recommendations

Becky was instructed to start looking for possible sources of xylene in her everyday activities.These sources could include: cigarettes, paint, spray paint, new carpet, new car, gasoline, dry cleaning, and cleaning solvents. Since low sulfur can represent high or chronic glutathione demand, the clinician gave Becky NAC and glycine.

Other Comments

Becky found her exposure to xylene came from her roommate, who is a smoker and was smoking indoors. At her three-month follow up exam, an Organix retest showed Becky's laboratory results had returned to normal, with a decrease in 2-methylhippurate and an increase in sulfur stores.