Autistic Child with Intermittent Constipation

Summary

This 5-year-old boy developed IBS symptoms at 18 months old, with intermittent constipation. His gross motor development is normal, but he has been diagnosed as autistic with severe behavior and allergic manifestations.

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History

Age

Gender

Male

Description of Results

A severe overgrowth of K. oxytoca was found. Note that the assay is able to keep on counting target genomes over many orders of magnitude. Here the oxytoca is present at 1.48 x 10⁹CFU/gm, and this child also shows concurrent extremely high levels of Rhodotorula sp. Incidence of Rhodotorula in our results is higher that from culture techniques, probably because it is identified microscopically, but grows poorly in usual culture media.

The drug resistance genes (aacA, aphD) indicate that erythromycin and levoflaxacin or other amino glycoside class antibiotics should be avoided, even though K. oxytoca in this patient is sensitive to these drugs. Drugs like amoxicillin may be used to reduce the K. oxytoca and Rhodotorula is sensitive to amphotericin B or fluconazole.

Plenty of metabolic activity is shown by the abundant SCFA and balanced percentages. Note the normal level of lactoferrin, showing lack of inflammatory involvement currently in this patient with very active IBS due to profound microbial overgrowth. The immune barrier is weakened as shown by low sIgA.

Recommendations

Antibacterials and antifungals according to sensitivities
Immune support with glutamine (consider colostrums) and glutathione
Investigate food intolerances to lower the loading of GALT

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