84-year-old Female with Chronic Diarrhea

Summary

An 84-year-old female presented with chronic, explosive diarrhea.

This content was created by the Metametrix Institute

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History

Age

Gender

Female

Description of Results

Low levels of the predominant bacterial species of Fusobacteria and Streptomyces (plus below normal Bifidobacter and Lactobacillus) with relative overgrowth of opportunistic bacteria were found.

No pathogens, yeast, parasites or drug resistance genes were found.

Here we see the metabolic fingerprint of the bacterial dysbiosis in the imbalanced propionate (L) and valerate (H) reflecting shifted total bacterial metabolic output. We also note the high lactoferrin produced by intra-epithelilal leukocytes to sequester iron as means of lowering the inflammation due to bacterial growth. The Metametrix Celiac Profile might be ordered to further diagnose this patient.

Low elastase 1 indicates that pancreatic insufficiency is suggested as one etiological origin of the disturbance. With this information we might construct the medical hypothesis that, as cortisol falls in the evening, the GI immune system activity increases with inflammatory responses. Concurrently, dietary proteins are passing undigested into the lower regions of the gut where they may be presenting as antigenic stimulants. Toxic bacterial metabolic products can increase sharply, along with direct bacterial enterotoxic effects, producing gasses and stimulating peristalsis that manifests as explosive diarrhea.

Recommendations

Submit Celiac Disease Profile specimen
Address diet – investigate food sensitivities with IgG profile
Add digestive enzymes and pre- & probiotics
Alternate high dose allicyn, berberine and oil of oregano (thymol)

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