8-Year Multiple Sensitivity, Oxidative Stress
Summary
Multiple abnormalities in a woman with multiple sensitivities.
This content was created by the Metametrix Institute
History
51-year-old female
Presenting symptoms:
- Food allergies and sensitivities
- Multiple chemical sensitivity
- Extreme fatigue and brain fog
- GI complaints - constipation
- Hives
- Acne Rosacea
- Cannot take supplements – too sensitive
Age
51
Gender
Female
Description of Results
Abundant Clostridia sp. and extremely prevalent E. coli
Elevated SCFA dominated by butyrate with little acetate
Elevated antigliadin antibody
Digestion & absorption appears normal
High ferritin and peroxides with low CoQ10, tocopherol and Mg suggesting oxidative stress
Low free androgen index as a potential anabolic deficit
Very high Cu with low K, Mg, Zn, Mn and Se
Very high Al
Low alpha- and undetectable gamma-tocopherol with very low CoQ10
Lipid peroxides in 5th quintile with extreme elevation of 8-OHdG
Very low vitamin D
Multiple low n-3 (ALA, DPA, DHA) and n-6 (LA, AA) PUFAs w/o elevated mead
Elevated palmitelaidic trans fatty acid
High pyroglutamate and benzoate indicating glycine deficit
Recommendations
The most compelling pattern is one of extreme oxidative stress, possibly due to toxic aluminum and copper levels. Toxic element metabolic impact may explain the porphyrin pathway abnormality, although the pattern is not reported specifically associated with aluminum effects. Exposure to aluminum should be immediately investigated and minimized and, if copper excess is confirmed, phlebotomy may be employed and avoiding copper-rich foods (esp. shellfish) can be advised. Add zinc to tolerance.
Antioxidants and vitamin D appear in urgent in need of repletion. The full range of lipid and water-soluble factors can be helpful to relieve the oxidative stress and restore redox balance. Use polyunsaturated fatty acid (PUFA) supplements with caution, in spite of the depressed tissue status because of the potential for exacerbating oxidative stress. Supplementation of PUFA-rich oils can be started as soon as follow-up testing indicates relief of the oxidative stress. Read on for further rationale regarding low PUFA.
The oxidative stress may be causing general anabolic process suppression as indicated by low testosterone and low levels of saturated (and other) fatty acids that can reflect suppressed hepatic LDL export. Aggressive addition of nutrient elements that are low in erythrocytes may be poorly tolerated because they stimulate the anabolic processes to produce greater oxidative stress.
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