Reactive Species and Antioxidant Markers

Summary

Normal cellular processes, ultraviolet rays from the sun, environmental pollutants and toxins, excessive intake of protein, total calories or alcohol, and even increased exercise, can increase reactive oxygen (ROS) and reactive nitrogen (RNS) species.

This content was created by the Metametrix Institute

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These reactive species can also react with other products leading to the production of new reactive species. One example of this is NO reacting with O2 -(superoxide) producing peroxynitrite (ONOO-) which has been shown to damage proteins, lipids and DNA. Damage from ROS and RNS has been suggested as a contributor to chronic diseases such as cancer, atherosclerosis, inflammatory disease, lens tissue disease, Alzheimer disease, and the aging process.

 

Markers of Reactive Species:

8-hydroxy-2-deoxyguanosine (8-OHdG)

Lipid Peroxides (TBARS)

p-hydroxyphenyllactate

Arachidonic acid

Interleukin-6 (IL-6)

 

Markers of Antioxidant Capacity:

Glutathione

Vitamins A, C, and E and ß-Carotene

Copper, Manganese, Selenium, Zinc, and Riboflavin