Mitochondrial Dysfunction and Disease

Summary

This article examines the structure and function of mitochondria, details the mechanisms by which acquired mitochondrial dysfunction can create a wide range of symptoms and provides a rational approach to treatment. John Neustadt, ND

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Neustadt J, “Mitochondrial Dysfunction and Disease.” Integrative Medicine. 2006 June/July 5(3): p.14-20.

Details

Many advances have been made in understanding the role mitochondria play in health, disease, and aging.  It is now understood that a wide range of seemingly unrelated disorders, from schizophrenia to diabetes, have underlying pathophysiological mechanisms in common - mitochondrial dysfunction, ROS production, and the accumulation of mtDNA damage.  The most sensitive and specific test for mitochondrial dysfunction is urinary organic acid analysis. Organic acid testing has the ability to detect dysfunction of mitochondrial energy production as well as the presence of functional nutrient deficiencies and toxins that are adversely affecting detoxification pathways.