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A collection of informative articles, white papers, and peer-reviewed published works to help patients and practitioners gain a better understanding of Functional Medicine and how Metametrix testing applies.
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A Case Report of a 53-Year-Old Female with Rheumatoid Arthritis and Osteoporosis: Focus on Lab Testing and CAM Therapies

Kara Fitzgerald, ND - Alternative Medicine Review

In this case, the patient presented with inflammatory arthritis of almost seven years’ duration. She described the pain in her hands, wrists, and elbows as frequently unbearable, rating it 8/10 to 10/10, with 10 being the highest level of pain.

The Effects of Persistent Organic Pollutants (POPs) in Weight Loss and How to Mitigate Them

Elizabeth Redmond, PhD, MMSc, RD and Terry Pollock, MS -

Research now indicates that a patient's levels of persistent organic pollutants (POPs) should be evaluated prior to weight loss. Because POPs are stored in body fat, weight loss can generate significant releases of toxicants into the body.

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President's Cancer Panel: Reducing Environmental Cancer Risk

National Cancer Institute: President's Cancer Panel -

With the growing body of evidence linking environmental exposures to cancer, the public is becoming increasingly aware of the unacceptable burden of cancer resulting from environmental and occupational exposures that could have been prevented through appropriate national action.

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Chlorinated Pesticides: Threats to Health and Importance of Detection

Walter Crinnion, ND - Alternative Medicine Review

Persistence of banned chlorinated pesticides in the environment poses an ongoing threat to health. Eight of the most commonly found and harmful chlorinated pesticides are reviewed in this article, along with the most common sources of exposure and possible action steps.

Importance of Sulfur Amino Acids

Metametrix - Article

Are we getting enough sulfur in our diets? This brief article covers the functions of sulfur amino acids, adverse effects of insufficiencies, and common food sources of these essential amino acids.

What Are Organic Acids?

Metametrix - Article

Organic acids are products of metabolism that can sensitively identify nutrient deficiencies that lead to metabolic roadblocks.

Important Markers of Neurological Inflammation: Kynurenate & Quinolinate


The kynurenine (KYN) pathway is a major route of L-tryptophan catabolism and operates as a mechanism of defense against intracellular pathogens and as a mediator of stress response signals to the brain.

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Understanding IgG4 Food Sensitivities

Metametrix - White Paper

This article explains IgG4 food sensitivities and their subclasses. It also compares the various types of IgG4 laboratory testing.

Changes in Whole Blood Fatty Acids Levels Following Whole Food Omega-3 Tuna Supplementation


This study follows previously known ideas that supplementing will adjust mean levels. It shows that in order to know if a single patient’s levels are adequate and reach a specific amount, that patient’s blood level must be tested.

Vitamin K Functions and Functional Markers


The role of vitamin K extends well beyond the regulation of blood clotting to impact bone formation, and development of heart disease, and possibly cancer.

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