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Summary:
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Conditions: |
Tests Ordered: |
Age: |
Gender: |
Date: |
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asthma
autism
myoclonus
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K90 ION
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11 |
M |
8/25/2003 |
History
This 11 y/o boy fits most criteria for diagnosis as autistic. He recently developed a myoclonus of rolling eyes, then head and arms, is a picky eater, has chronic asthma, excema, and abdominal pain and vomiting. His blood type is O+.
Using a gluten- and casein-free diet gave only mild improvement.
Description of Results
Several markers point to nutrient deficiencies, but the salient feature may be the significant elevation of the marker for invasiveness of candidiasis, D-arabinitol. The other compounds associated with intestinal yeast are in acceptible ranges. These compounds may be more associated with stages of yeast growth that add to toxic burden but may be present without invasiveness of the yeast that so greatly elevates immune system aggressiveness. (See Figure below labeled "Yeast - NO pattern 4.gif".)
In addition, the data show a pattern suggestive of limitation in arginine availability for NO synthesis consisting of low plasma arginine, high urinary isocitrate, and upper fourth quintile urinary orotate. Poor utilizaiton of lysine is indicated by the plasma lysine that is almost out of the top of the range.
Recommendations
Antifungal, n-3 and n-6 oils, amino acids with high arginine proportion, carnitine and vitamin B12 (or methylcobalamin).
Other Comments
There is still great difficulty in knowing when intestinal yeast may be a part of clinical presentaions. The finding of elevated D-arabinitol in the absence of any products of bacterial overgrowth helps to identify candidates for antifungal therapies. Because of the immune response potentiation by NO, any concurrent signs of restriction in the availability of arginine for iNOS utilization is taken as a sign that the patient is a candidate for extra arginine. In this case there are multiple signs that the urea cycle may be demainding extra arginine.
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Lab Data
Figure . Yeast - NO pattern 1.gif
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Figure . Yeast - NO pattern 2.gif
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Figure . Yeast - NO pattern 3.gif
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Figure . Yeast - NO pattern 4.gif
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