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Every Woman Should Know Her Risk for Breast Cancer.
Now She Can with a Simple Urine Test!
When a major study of hormone replacement therapy in women was recently discontinued, clinicians and patients alike were left with unanswered questions. Why are certain tissues, such as the breast, susceptible to estrogen-induced cancer? Why are some women susceptible, but not others? Researchers at Rockefeller University have found that the body metabolizes estrogens into several different metabolites that can impact cancer development.
One metabolite, 2-hydroxyestrone (2-OHE1), tends to inhibit cancer growth. Another, 16-a-hydroxyestrone (16-a-OHE1), actually encourages tumor development. A woman’s "biochemical individuality" determines which of these metabolites predominates. Studies have shown that measuring the ratio of these two metabolites provides an important indication of risk for future development of estrogen-sensitive cancers. The studies also show that this risk is modifiable!
The Estronex™ 2/16 Test from Metametrix Clinical Laboratory measures the ratio of these two critical estrogen metabolites from a single urine specimen. Estronex 2/16 ratios less than 2.0 indicate increasing long-term risk for breast, cervical, and other estrogen-sensitive cancers. Importantly, nutritional interventions can help raise Estronex 2/16 ratios and decrease long-term risk.
Read more in "Estrogen Metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites"
Order patient brochures on the Estronex Profile by contacting us!
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The Estronex™ 2/16 Test features:
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A simple first-morning urine specimen; no blood draw is necessary.
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Economical, so you can retest often to monitor therapy.
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Bone Resorption Test can be added for osteoporosis risk assessment at only a small incremental cost.
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Clinician Info
| Test name: |
0142 - Estronex™ 2/16 Assay 0145 - Estronex™ 2/16 with Bone Resorption
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| Description: |
The balance of anti- and pro-carcinogenic metabolites of estrogen
may be investigated with this test that measures the 2- and 16-alpha-
hydroxyderivatives of estrone and estradiol. If the 2/16 ratio is too low, the use of foods or supplements containing I3C or DIM can
stimulate hepatic P450 enzymes to increase the favorable 2-hydroxy
derivatives.
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| Method: |
EIA, Chemiluminescence, Spectrophotometry |
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| Turnaround time: |
7-10 days, 8 days average |
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Analytes:
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2-Hydroxyestrogens (sum of 2-hydroxyestradiol and 2-hydroxyestrone) 16-alpha-Hydroxyestrone Creatinine
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CPT codes:
| 82679 x2 |
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| Estrone (2- and 16-alpha-hydroxyestrones) |
| 82570 |
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| Creatinine |
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Selected Diet and Lifestyle Factors Are Associated with Estrogen Metabolitesin a Multiracial/Ethnic Population of Women
MaryFran R. Sowers, Sybil Crawford, Daniel S. McConnell, John F. Randolph, Jr. J. Nutr. 136: 1588–1595, 2006.
Effect of flaxseed consumption on urinary estrogen metabolites in postmenopausal women.
Haggans CJ, Hutchins AM, Olson BA, Thomas W, Martini MC, Slavin JL. Nutrition & Cancer. 1999;33(2):188-195.
Effect of energy deficiency on estrogen metabolism in premenopausal women.
Westerlind KC, Williams NI. Med Sci Sports Exerc. 2007 Jul;39(7):1090-7.
Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients:
a pilot study comparing pre- and post-operative levels.
Klug TL, Bågeman E, Ingvar C, Rose C, Jernström H. Mol Genet Metab. 2006 Dec;89(4):381-9. Epub 2006 Sep 15.
2-OH-estradiol, an endogenous hormone with neuroprotective functions.
Teepker M, Anthes N, Krieg JC, Vedder H. J Psychiatr Res. Nov-Dec 2003;37(6):517-523.
Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16alpha-hydroxyestrone ratio in premenopausal and postmenopausal women.
Muti P, Bradlow HL, Micheli A, et al. Epidemiology. Nov 2000;11(6):635-640.
A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals.
Minich DM, Bland JS. Nutr Rev. 2007 Jun;65(6 Pt 1):259-67.
Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women.
Fowke JH, Longcope C, Hebert JR. Cancer Epidemiol Biomarkers Prev. 2000;9(8):773-779.
Lower lifetime occurrence of breast cancer and cancers of the reproductive system among former college athletes.
Frisch RE, Wyshak G, Witschi J, Albright NL, Albright TE, Schiff I. Int J Fertil. May-Jun 1987;32(3):217-225.
The effect of oxidative stress on ERalpha and ERbeta expression.
Tamir S, Izrael S, Vaya J. J Steroid Biochem Mol Biol. Aug 2002;81(4-5):327-332.
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