Organix™ Dysbiosis - Urine

Overview

Clinician Info

CPT Codes

Kit Instructions

Sample Reports

Interpretive Guide

References

Organix Dysbiosis Profile*

The Russian scientist Elie Metchnikoff (1845 - 1916) popularized the idea of "Dys-symbiosis” or “Dysbiosis," describing an imbalance in the microecology of the digestive tract. Intestinal dysbiosis contributes to many health problems, ranging from IBS, acne, and food allergies to chronic fatigue and depression. The Metametrix Organix Dysbiosis Profile measures the by-products of microbial metabolism that are excreted in urine, making it particularly useful in detecting the presence of pathogenic microbial overgrowth. Ordered alone, the Organix Dysbiosis Profile allows you to assess microbial overgrowth and guide and monitor therapy.

Is urine or stool better for assessing dysbiosis?

Although stool testing has been the traditional method for assessing dysbiosis, "there is increasing evidence that the fecal microbiota does not mirror the colonic situation."[1] This results in a high degree of false negatives and a greater potential to miss a clinically significant dysbiotic situation. In addition to a wealth of information about human metabolism, urine contains unique products of microbial metabolism. With the exception of hippurate, the compounds measured in the Organix Dysbiosis Profile are not normally produced by human cells. Unfriendly intestinal microorganisms, however, can manufacture them in relatively high quantities. These compounds are absorbed into the blood from the intestines and eventually appear in the urine.

Microbial overgrowth can lead to a wide variety of symptoms due to reactions to the toxic products produced by bacteria, parasites, or fungi. Various patterns of the compounds appear elevated in conditions of general intestinal microbial overgrowth.

Clinical effects can be as diverse as:

Behavioral Disorders

Chronic Fatigue
Depression
Headache
Immune Dysfunction
Insomnia
Irritable Bowel Syndrome
Joint Pain
Learning Disorders
Nutritional Deficiencies
Skin Disorders

*Some analytes may not be reported in New York profiles. Please see Clinician Info and CPT Codes for details

The Metametrix Organix Dysbiosis Profile features:

An easy overnight urine specimen, resulting in better patient acceptance than stool testing.
Discrimination between microbial classes, allowing more focused therapies.
D-arabinitol, a specific marker for Candida sp.
D-lactate, an indicator of L. acidophilus overgrowth and carbohydrate malabsorption.
As a component of the Organix Profile, it can be used as an economical follow-up to monitor therapy.