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Organix™ Comprehensive - Urine

Chronically Ill Patients Want an Answer, Not a Label

Identifying the cause of chronic illness is the first step toward achieving a favorable outcome. Integrative clinicians rely on the Organix™ Profile to reveal the nutritional and metabolic basis of patient symptoms, just as traditional practitioners might use a serum chemistry to establish a diagnostic baseline. The Organix Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes.

Organic acids are metabolic intermediates produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Accumulation of specific organic acids in urine often signals a metabolic inhibition or block. This may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.

Organix Profiles Include:

  • Organix Comprehensive* - The complete organic acids profile
  • Organix Basic - Great for follow up testing when dysbiosis markers aren't needed
  • Organix Dysbiosis* - Measures the by-products of microbial metabolism to access overgrowth and guide and monitor therapy

*Some analytes may not be reported in New York profiles. Please see Clinician Info and CPT Codes for details

 

 

From a single urine specimen, the Organix Profile provides important information in the areas of:

  • Vitamin and mineral insufficiencies
  • Amino acid insufficiencies like carnitine and NAC
  • Oxidative damage and anti-oxidant sufficiency markers
  • Indicators to assess detoxification sufficiency
  • The best functional markers of B-complex deficiency
  • Neurotransmitter metabolites to assess CNS function
  • Mitochondrial energy production assessment via citric acid cycle components
  • Methylation sufficiency status
  • Lipoic acid and CoQ10 sufficiency markers
  • Specific dysbiosis markers for bacterial and yeast overgrowth

 

Clinician Info
Test name: 0091 - Organix™ Comprehensive Profile
0088 - Neopterin/Biopterin Profile*
Description: The Organix™ Comprehensive Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic acids are metabolic intermdiates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the analytes are markers of intestinal bacterial or yeast overgrowth
Method: LC/MS-MS, Spectrophotometry
Turnaround time: 8-14 days, 12 days average
Analytes: FATTY ACID METABOLISM
Adipate
Suberate
Ethylmalonate


CARBOHYDRATE METABOLISM
Pyruvate
Lactate
Beta-Hydroxybutyrate


ENERGY PRODUCTION (CITRIC ACID CYCLE)
Citrate
cis-Aconitate
Isocitrate
Alpha-Ketoglutarate
Succinate
Fumarate
Malate
Hydroxymethylglutarate


B-COMPLEX VITAMIN MARKERS
Alpha-Ketoisovalerate
Alpha-Ketoisocaproate
Alpha-Keto-Beta-Methylvalerate
Xanthurenate
Beta-Hydroxyisovalerate


METHYLATION COFACTOR MARKERS
Methylmalonate
Formiminoglutamate


NEUROTRANSMITTER MEATBOLISM MARKERS
Vanilmandelate
Homvanillate
5-hydroxyindoleacetate
Kynurenate
Quinolinate


OXIDATIVE DAMAGE AND ANTIOXIDANT MARKERS
p-Hydroxyphenyllactate
* 8-Hydroxy-2'-deoxyguanosine


DETOXIFICATON INDICATORS
2-Methylhippurate
Orotate
Glucarate
Alpha-Hydroxybutyrate
Pyroglutamate
Sulfate


BACTERIAL-GENERAL
Benzoate
Hippurate
Phenylacetate
Phenylpropionate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
Indican
Tricarballylate


L.ACIDOPHILUS/GENERAL BACTERIA
D-Lactate


CLOSTRIDIAL SPECIES
3,4 Dihydroxyphenylpropionate


YEAST/FUNGAL
* D-Arabinitol
Creatinine

*Not reported in New York profiles


CPT codes:

84378 - Arabinitol, single, quantitative *
82507 - Citrate
82570 - Creatinine
83150 - Homovanillate
83497 - 5-Hydroxyindoleacetate
83789 - LC/MS-MS, NES; quantitative:
8-Hydroxy-2'-deoxyguanosine *
83789 - Indican
83605 x2 - D-Lactate *
84210 - Pyruvate
84392 - Sulfate
84585 - Vanilmandelate
83921 x35 - Organic acid, single, quantitative
 
* Not reported in New York profiles
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Organix Comprehensive References
 

Urinary and faecal excretion of metabolites of tyrosine and phenylalanine in a patient with cystic fibrosis and severely impaired amino acid absorption.
Van der Heiden C, Wadman SK, Ketting D, et al. Clin Chim Acta. 1971;31(1):133-141.

Metabolic acidosis due to D-lactate.
Mason PD: Br Med J (Clin Res Ed) 1986, 292(6528):1105-1106.

Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia.
Bongaerts GP, Tolboom JJ, Naber AH, Sperl WJ, Severijnen RS, Bakkeren JA, Willems JL. Microb Pathog 1997, 22(5):285-293.

D-arabinitol--a marker for invasive candidiasis.
Christensson B, Sigmundsdottir G, Larsson L. Med Mycol 1999, 37(6):391-396.

Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility.
Gershon MD. Aliment Pharmacol Ther. Nov 2004;20 Suppl 7:3-14.