IgG4 Food Antibodies - Bloodspot 30

A Non-invasive Approach to Food Allergy Testing

Why choose the Bloodspot IgG Food Antibodies Profile?

From a simple finger stick, the Bloodspot IgG4 Food Antibodies Profile offers a non-invasive alternative to a blood draw in determining IgG food reactions. Responses to 30 different foods are tested, and responses are categorized by severity from borderline to mild, moderate, or severe on the report.

Features of blood spot testing:

• Easy to implement in any practice and great option for follow-up testing
• Does not require venipuncture
• Cost-effective testing and therapy
• Easy enough for patients to use at home
• Offers the same levels of precision and reproducibility as standard methods

Why choose IgG food allergy testing?

IgG4 antibodies are associated with non-atopic or "delayed" food reactions that can worsen or contribute to many health conditions. Food sensitivities can occur at any age, triggering a wide range of symptoms. The Bloodspot IgG4 Food Antibody Profile measures levels of IgG4 antibodies specific to 30 commonly offending foods clearly identifying foods causing patient reactions. Testing aids the clinician in the specific dietary change that is needed, helping to achieve positive outcomes sooner, even when combined with elimination or provocation testing.

Common offending frequently eaten foods typically hard to avoid:

• Milk
• Corn
• Wheat
• Egg
• Foods processed with molds such as black tea, breads, and fruit juices

Test name:	0076* - IgG4 Food Antibodies - Bloodspot 30
Description:	The Bloodspot™ IgG Food Antibody Assay is a blood spot test that measures the total IgG levels that react to common food antigens. The test kit is simple enough for the patient to use at home.
Method:	ELISA
Turnaround time:	7-14 days, 10 days average
Antigens:	Almond Aspergillus Mold Beef Cantaloupe Cashew Chicken Corn Crab Egg, Whole Garlic Lobster Milk Mustard Greens Oat Orange Peanut Pea, Green Pinto Bean Pork Rice Salmon Shrimp Soybean Strawberry Sunflower Tomato Tuna Turkey Walnut, English Wheat *Not available in New York

86001 x 30 - Allergen Specific IgG quantitative or semiquantitative each allergen

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	References Allergix IgG4 Food Antibodies
	Immunologic and clinical responses to parenteral immunotherapy in peanut anaphylaxis--a study using IgE and IgG4 immunoblot monitoring. Bullock, R.J., D. Barnett, and M.E. Howden, Allergol Immunopathol (Madr), 2005. 33(5):250-6. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Zar, S., et al., Scand J Gastroenterol, 2005. 40(7): p. 800-7. IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis. O'Farrelly, C., et al., Immunol Invest, 1989. 18(6): p. 753-64. The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis. Hvatum, M., et al., Gut, 2006. 55(9): p. 1240-7. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. Pediatr Allergy Immunol. 2007 Feb;18(1):63-70. Food sensitivity case report Betty Wedman-St Louis Original Internist,  Sept, 2006 Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. Drisko J, Bischoff B, Hall M, McCallum R. J Am Coll Nutr. 2006 Dec;25(6):514-22. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing. Dixon, H. Otolaryngol Head Neck Surg 2000;123:48-54 Breaking the rules. Aalbers RC, Schuurman, J. IgG Immunology, 2002, 105 9-19. A subclass IgG4 specific antigen binding radioimmunoassay (RIA): comparison of IgG and IgG4 antibodies of food and inhaled antigens in adult atopic dermatitis after desensitization treatment and during development of antibody responses in children. Rowntree, S., Platts-Mills, T.A, Cogeswell, MB. J ALLERGY CLIN IMMUNOL 1981;80:622-30. Non-IgE antibody mediated mechanisms in food allergy .Halpern, G.M., Scott, J.R. Annals of Allergy, Vol 58, January 1987. Assessing adherence to a rotary diversified diet, a treatment for 'environmental illness. Taylor JP, Krondl MM, Csima AC. J Am Diet Assoc. 1998 Dec;98(12):1439-44. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. Pediatr Allergy Immunol. 2007 Feb;18(1):63-70.