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Next Generation Food Sensitivity Testing
Breakthroughs in IgG Antibody Testing!
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New patent pending IgG4 assay
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First test to quantitate IgG4
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Eliminate non-specific binding therefore eliminate false positives without rejecting true positives!
Food Antibody Testing
IgE
The less common but widely recognized atopic food sensitivities, such as an immediate reaction to peanuts or shellfish, are IgE-mediated responses.
IgG4
IgG4 antibodies are associated with non-atopic or "delayed" food reactions that can worsen or contribute to many different health problems and are considered the most common form of immunologically mediated food intolerance. These reactions are more difficult to notice since they can occur hours or even days after consumption of an offending food. In some cases, a person may eat a food for several days before developing a reaction to it, so they may not realize the link between the food and their symptoms. These "hidden" food allergies are caused by increasing blood levels of IgG4 antibodies in reaction to specific foods. Often the offenders are frequently eaten foods that are hard to avoid, such as milk, corn, and wheat. Simultaneous high levels of many IgG food-specific antibodies are generally related to intestinal hyperpermeability.
Bloodspot IgG4*
From a simple finger stick, the Bloodspot™ IgG4 Food Antibody Profile measures levels of IgG4 antibodies specific to 30 commonly offending foods. It clearly identify those foods that may be causing health problems, helping to achieve positive outcomes sooner, even when combined with elimination/provocation testing.
*Bloodspot profile not available in New York |
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Food sensitivities can occur at any age, triggering many different symptoms and contributing to a variety of disorders, including:
Metametrix offers a choice of testing:
Special pricing when you order serum IgG and IgE food antibody testing together.
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Clinician Info
| Test name: |
0075 - IgG4 Food Antibodies 90 Antigens
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| Description: |
The Allergix IgG4 antibody is related to “delayed” or non-atopic food reactions that exacerbate or contribute to many different health problems. Simultaneous high levels of many IgG4 food-specific antibodies are generally associated with intestinal hyperpermeability. This profile measures the IgG4 levels in serum that react to 90 different foods, including commonly eaten foods such as corn, milk, egg, and wheat. A food reaction patient guide is provided with each test result. |
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| Method: |
ELISA |
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| Turnaround time: |
4-7 days, 7 days average |
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Antigens:
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Almond Apple Apricot Asparagus Aspergillus Mold Avocado Banana Barley Bean, String Beef Black Pepper Blueberry Broccoli Cabbage Cantaloupe Carrot Casein Cashew Cauliflower Celery Chicken Chocolate Cinnamon Clam Coconut Codfish Coffee Corn Crab Cranberry Cucumber Egg White Egg Yolk Flounder Garlic Ginger Grape Grapefruit Halibut Honeydew Lamb Lemon Lentil Lettuce Lima Bean Lobster Mackerel Malt Milk Mushroom Mustard Greens Navy Bean Oat Olive Onion Orange Oyster Pea, Green Peach Peanut Pear Pecan Pepper, Green Pineapple Pinto Bean Pistachio Pork Potato Rice Rye Salmon Sesame Shrimp Soybean Spinach Strawberry Sunflower Sweet Potato Tea Tomato Trout Tuna Turkey Vanilla Watermelon Walnut, English Wheat Yeast, Baker's Yeast, Brewer's Zucchini
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CPT codes:
| 86001 x 90 |
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Allergen Specific IgG quantitative or semiquantitative each allergen |
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Immunologic and clinical responses to parenteral immunotherapy in peanut anaphylaxis--a study using IgE and IgG4 immunoblot monitoring.
Bullock, R.J., D. Barnett, and M.E. Howden, Allergol Immunopathol (Madr), 2005. 33(5):250-6.
Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome.
Zar, S., et al., Scand J Gastroenterol, 2005. 40(7): p. 800-7.
IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis.
O'Farrelly, C., et al., Immunol Invest, 1989. 18(6): p. 753-64.
The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis.
Hvatum, M., et al., Gut, 2006. 55(9): p. 1240-7.
The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis.
Noh G, Ahn HS, Cho NY, Lee S, Oh JW. Pediatr Allergy Immunol. 2007 Feb;18(1):63-70.
Food sensitivity case report
Betty Wedman-St Louis Original Internist, Sept, 2006
Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics.
Drisko J, Bischoff B, Hall M, McCallum R. J Am Coll Nutr. 2006 Dec;25(6):514-22.
Treatment of delayed food allergy based on specific immunoglobulin G RAST testing.
Dixon, H. Otolaryngol Head Neck Surg 2000;123:48-54
Breaking the rules.
Aalbers RC, Schuurman, J. IgG Immunology, 2002, 105 9-19.
A subclass IgG4 specific antigen binding radioimmunoassay (RIA): comparison of IgG and IgG4
antibodies of food and inhaled antigens in adult atopic dermatitis after desensitization treatment and during development of antibody responses in children.
Rowntree, S., Platts-Mills, T.A, Cogeswell, MB. J ALLERGY CLIN IMMUNOL 1981;80:622-30.
Non-IgE antibody mediated mechanisms in food allergy
.Halpern, G.M., Scott, J.R. Annals of Allergy, Vol 58, January 1987.
Assessing adherence to a rotary diversified diet, a treatment for 'environmental illness.
Taylor JP, Krondl MM, Csima AC. J Am Diet Assoc. 1998 Dec;98(12):1439-44.
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