IgG4 Food Antibodies 90 - Serum

IgG4 Delayed Food Reactions – More common than you think

What is an IgG4 response?

IgG4 antibodies are associated with non-atopic or "delayed" food reactions that can worsen or contribute to many different health problems. These reactions are considered the most common form of immunologically mediated food intolerance. An IgG4 response to food is actually more common than the IgE response, which causes an immediate reaction. IgG4 acts as a blocking antibody, protecting the individual from potentially fatal IgE reactions. These reactions are more difficult to notice since they can occur hours or even days after consumption of an offending food. In some cases, a person's reaction to a food may occur several days after eating the offending food and the link between the food and their symptoms may not be connected. These "hidden" food allergies are caused by increasing blood levels of IgG4 antibodies in reaction to specific foods.

Metametrix Innovation in IgG Antibody Testing

• New patent-pending IgG4 assay allows our test to show less false positives leading to better patient compliance.
• First test to quantitate IgG4
• Eliminates non-specific binding, lowering false positives without rejecting true positives

Common offending frequently eaten foods typically hard to avoid:

• Milk
• Corn
• Wheat
• Egg
• Foods processed with molds such as black tea, breads, and fruit juices

Metametrix offers two Allergix IgG4 Food Antibody Profiles:

• IgG4 Food Antibody Profile – measures serum levels of IgG4 antibodies specific to 90 food antigens. A four-day rotation diet is included.
• Bloodspot IgG4 Food Antibody Profile – measures levels of IgG4 antibodies specific to 30 commonly offending foods from an easy-to-use finger stick.  A four-day rotation diet is included.

Special Pricing is available for the following Allergix combination profiles:

• 0270 - IgG4 and IgE Food Antibodies
• 0278 - IgG4 Food Antibodies and Celiac Profile

“  An exclusion diet based on food-specific serum IgG4 antibody testing may provide a useful adjunct in IBS patients, and testing may provide an objective and quick method for selecting an exclusion diet for treating such patients.  ”

- Scand J Gastroenterol. 2005 Jul;40(7):8007

Test name:	0075 - IgG4 Food Antibodies 90 Antigens 0270 - IgG4 and IgE Food Antibodies 0271 - IgG4 and IgE Food Antibodies - NY 0278 - IgG4 Food Antibodies and Celiac Profile
Description:	The Allergix IgG4 antibody is related to “delayed” or non-atopic food reactions that exacerbate or contribute to many different health problems. Simultaneous high levels of many IgG4 food-specific antibodies are generally associated with intestinal hyperpermeability. This profile measures the IgG4 levels in serum that react to 90 different foods, including commonly eaten foods such as corn, milk, egg, and wheat. A food reaction patient guide is provided with each test result.
Method:	ELISA
Turnaround time:	4-7 days, 7 days average
Antigens:	Almond Apple Apricot Asparagus Aspergillus Mold Avocado Banana Barley Bean, String Beef Black Pepper Blueberry Broccoli Cabbage Cantaloupe Carrot Casein Cashew Cauliflower Celery Chicken Chocolate Cinnamon Clam Coconut Codfish Coffee Corn Crab Cranberry Cucumber Egg White Egg Yolk Flounder Garlic Ginger Grape Grapefruit Halibut Honeydew Lamb Lemon Lentil Lettuce Lima Bean Lobster Mackerel Malt Milk Mushroom Mustard Greens Navy Bean Oat Olive Onion Orange Oyster Pea, Green Peach Peanut Pear Pecan Pepper, Green Pineapple Pinto Bean Pistachio Pork Potato Rice Rye Salmon Sesame Shrimp Soybean Spinach Strawberry Sunflower Sweet Potato Tea Tomato Trout Tuna Turkey Vanilla Watermelon Walnut, English Wheat Yeast, Baker's Yeast, Brewer's Zucchini

86001 x 90 - Allergen Specific IgG quantitative or semiquantitative each allergen

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	References Allergix IgG4 Food Antibodies
	Immunologic and clinical responses to parenteral immunotherapy in peanut anaphylaxis--a study using IgE and IgG4 immunoblot monitoring. Bullock, R.J., D. Barnett, and M.E. Howden, Allergol Immunopathol (Madr), 2005. 33(5):250-6. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Zar, S., et al., Scand J Gastroenterol, 2005. 40(7): p. 800-7. IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis. O'Farrelly, C., et al., Immunol Invest, 1989. 18(6): p. 753-64. The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis. Hvatum, M., et al., Gut, 2006. 55(9): p. 1240-7. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. Pediatr Allergy Immunol. 2007 Feb;18(1):63-70. Food sensitivity case report Betty Wedman-St Louis Original Internist,  Sept, 2006 Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. Drisko J, Bischoff B, Hall M, McCallum R. J Am Coll Nutr. 2006 Dec;25(6):514-22. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing. Dixon, H. Otolaryngol Head Neck Surg 2000;123:48-54 Breaking the rules. Aalbers RC, Schuurman, J. IgG Immunology, 2002, 105 9-19. A subclass IgG4 specific antigen binding radioimmunoassay (RIA): comparison of IgG and IgG4 antibodies of food and inhaled antigens in adult atopic dermatitis after desensitization treatment and during development of antibody responses in children. Rowntree, S., Platts-Mills, T.A, Cogeswell, MB. J ALLERGY CLIN IMMUNOL 1981;80:622-30. Non-IgE antibody mediated mechanisms in food allergy .Halpern, G.M., Scott, J.R. Annals of Allergy, Vol 58, January 1987. Assessing adherence to a rotary diversified diet, a treatment for 'environmental illness. Taylor JP, Krondl MM, Csima AC. J Am Diet Assoc. 1998 Dec;98(12):1439-44. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. Pediatr Allergy Immunol. 2007 Feb;18(1):63-70.