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Lipid Peroxides
Lipid peroxides are the products of chemical damage done by oxygen free radicals to the polyunsaturated fatty acids of cell membranes. This test is an assay of total thiobarbituric acid-reactive substances (TBARS) in serum using HPLC. The HPLC separation step isolates the TBARS from potential interfering compounds that can give false elevations in a simple colorimetric assay. The results provide a measure of total serum lipid peroxidation, an indicator of whole body free radical activity. High levels of lipid peroxides are associated with cancer, heart disease, stroke, and aging. |
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Clinician Info
| Test name: |
0051- Lipid Peroxides
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| Description: |
Lipid peroxides are the products of chemical damage done by oxygen free radicals to the polyunsaturated fatty acids of cell membranes. This test is an assay of total thiobarbituric acid-reactive substances (TBARS) in serum using HPLC. The HPLC separation step isolates the TBARS from potential interferring compounds that can give false elevations in a simple colorimetric assay. The results provide a measure of total serum lipid peroxidation, an indicator of whole body free radical activity. High levels of lipid peroxides are associated with cancer, heart disease, stroke, and aging. |
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| Method: |
HPLC |
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| Turnaround time: |
6-8 days, 7 days average |
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Analytes:
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Lipid peroxides
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CPT codes:
| 82491 |
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HPLC, single analyte NES: Lipid peroxides |
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Radical mechanisms in relation to tissue injury.
Slater, T.F., et al., Free Proc Nutr Soc, 46(1). 1-12, 1987.
Mechanisms and consequences of lipid peroxidation in biological systems.
Sevanian, A. and P. Hochstein, Annu Rev Nutr, 5. 365-90, 1985.
Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.
Satoh, K., Clin Chim Acta, 90(1). 37-43, 1978.
The effect of alpha-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people.
Wartanowicz, M., et al., Ann Nutr Metab, 28(3). 186-91, 1984.
Clinical oxidation parameters of aging.
Voss P, Siems W. Free Radic Res. 2006 Dec;40(12):1339-49.
Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications.
Kesavulu MM, Giri R, Kameswara Rao B, Apparao C. Diabetes Metab. 2000 Nov;26(5):387-92.
Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease.
Rumley AG, Woodward M, Rumley A, Rumley J, Lowe GD. QJM. 2004 Dec;97(12):809-16.
Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes.
Jacob RA, Aiello GM, Stephensen CB, Blumberg JB, Milbury PE, Wallock LM, Ames BN. J Nutr. 2003 Mar;133(3):740-3.
Lipoperoxidation products and thiol antioxidants in chromium exposed workers.
Goulart M, Batoréu MC, Rodrigues AS, Laires A, Rueff J. Mutagenesis. 2005 Sep;20(5):311-5. Epub 2005 Jun 28.
Lipid peroxidation in workers exposed to hexavalent chromium.
Huang YL, Chen CY, Sheu JY, Chuang IC, Pan JH, Lin TH. J Toxicol Environ Health A. 1999 Feb 26;56(4):235-47.
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