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Condition and Nutrition Assessment Table
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Amino Acids 40 - Urine
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Overview
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Clinician Info
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CPT Codes
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Kit Instructions
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Sample Reports
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Interpretive Guide
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References
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Amino Acids in Urine—A Measure of Levels in Recent Dietary Intake
Amino Acids 40 Urine Profile
The urine profile can aid in determining and monitoring metabolic pathways, information about hepatic and renal function, the status of medical conditions, and amino acid balance. Urine may be influenced by dietary intake. Evaluation of amino acid identifies the status of essential, branched chain, and other non-essential amino acids, as well as several functional categories, such as neuroendocrine, vascular and detoxification, and functional vitamin and mineral deficiencies are reported. This profile is an ideal option when venipuncture services are limited.
Why is amino acid testing important?
Amino acids, known as the "building blocks" of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function including the formation of ligaments, tendons, bones, as well as antibodies and regulation of enzymes and blood transport proteins. Twenty different amino acids are used to synthesize proteins.
The human body can synthesize all of the amino acids necessary to build proteins except for ten called the "essential amino acids". These ten must be included in the diet or supplemented to be in adequate supplies. Failure to obtain enough of even one of these essential amino acids has serious health implications and can result in degradation of the body's proteins. Muscle and other protein structures may be dismantled to obtain the amino acid that is needed.
As a result, amino acids have more diverse functions than any other nutrient group, including:
- Gastrointestinal function
- Cellular energy production
- Detoxification
- Neurotransmitter metabolism
- Muscle catabolism
Collagen
Nutritional markers
Vascular function
Clinical application
Conditions associated with amino acid changes in urine:
- Inhertied metabolic disorders
- Starvation/Malnutrition
- Protient inake/digestion
- Alcoholism
- Osteoporosis
Bladder tumors
Cushing’s Disease
Chronic Fatigue Syndrome
Celiac disease
Muscle catabolism
| Test name: |
0012 - Amino Acids - 40 analytes
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| Description: |
The urine amino acid profile reports levels of essential amino acids and their derivatives in categories. Functional vitamin and mineral deficiencies and diagnosis of metabolic disorders, including neuroendocrine, muscle wasting, and bone loss, can be determined from a urine amino acid analysis. A 24-hour urine collection gives the most accurate analysis of urine amino acids.
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| Method: |
Reversed Phase UHPLCS Method |
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| Turnaround time: |
7-14 days, 10 days average |
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Analytes:
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1-Methylhistidine 3-Methylhistidine Alanine Alpha-Aminoadipic Acid Alpha-Amino-N-Butyric Acid Anserine Arginine Asparagine Aspartic Acid Beta-Alanine Beta-Aminoisobutyric Acid Carnosine Citrulline Cystahionine Cystine Ethanolamine Gamma-Aminobutyric Acid Glutamic Acid Glutamine Glycine Histidine Homocystine Hydroxylysine Hydroxyproline Isoleucine Leucine Lysine Methionine Ornithine Phenylalanine Phosphoethanolamine Phosphoserine Proline Sarcosine Serine Taurine Threonine Tryptophan Tyrosine Valine
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| 82139 |
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Amino acids, 6 or more, quantitative |
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ReferencesAmino Acids Urine
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Plasma and urinary amino acids and selected sulfur metabolites in young men fed a diet devoid of methionine and cystine.
Lakshmanan FL, Perera WD, Scrimshaw NS, Young VR. Am J Clin Nutr. 1976;29(12):1367-1371.
Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration.
Garde AH, Hansen AM, Kristiansen J, Knudsen LEAnn. Occup Hyg. Mar 2004;48(2):171-179.
Correlation between plasma and urine phenylalanine concentrations.
Boulos M, Boulat O, Van Melle G, Guignard JP, Matthieu JM. Biol Neonate. 2004;86(1):6-9.
Tyrosine and glutamic acid in plasma and urine of patients with altered thyroid function.
Belanger R, Chandramohan N, Misbin R, Rivlin RS. Metabolism. 1972;21(9):855-865.
Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition.
Kopple JD, Vinton NE, Laidlaw SA, Ament ME. Am J Clin Nutr. 1990;52(5):846-853.
High predictivity of galactosyl-hydroxylysine in urine as an indicator of bone metastases from breast cancer.
Moro L, Gazzarrini C, Modricky C, et al. Clin Chem. May 1990;36(5):772-774.
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