|
|
The Body’s Fundamental Building Blocks
Amino acids make up proteins found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function. As a result, amino acids have more diverse functions than any other nutrient group, including:
- Cellular energy production
- Formation of ligaments, tendons, and bones
- Formation of antibodies
- Formation and regulation of enzymes and blood transport proteins
Plasma Amino Acids
Fasting plasma levels represent a homeostatic balance between supply and utilization of amino acids. Problems in amino acid metabolism are revealed by the amino acids and metabolites that are reported in categories according to function.
Plasma 40 Profile
The plasma profile can illuminate problems in amino acid absorption by determining essential amino acids imbalances. Additionally, evaluation of essential amino acid derivatives show neuroendocrine metabolic disorders as well as functional vitamin and mineral deficiencies. Also assessed are amino acid derivatives focusing on energy, sulfation, muscle wasting, and bone loss.
Urine Amino Acids
Urine amino acid analysis is better for discriminating the metabolic effects of short-term (24 to 48 hour) dietary changes than is plasma analysis. Conversely, urine analysis requires more rigorous dietary control than plasma analysis in order to give an accurate picture of a patient’s steady-state amino acid sufficiency and metabolism.
Urine 40 Profile
The urine amino acid profile reports levels of essential amino acids and their derivatives in categories. Functional vitamin and mineral deficiencies and diagnosis of metabolic disorders, including neuroendocrine, muscle wasting, and bone loss, can be determined from a urine amino acid analysis. A 24-hour urine collection gives the most accurate analysis of urine amino acids.
Customized Amino Acid Formula
A formula for a customized amino acid blend individually formulated, based on your patient’s specific test results, is provided with every plasma amino acid test result. These customized amino acid formulations provide appropriate amounts of essential and conditionally essential amino acids, delivered in a balanced ratio to offset the risk of imbalance sometimes seen with the use of single amino acid supplements. This blend can be made by many compounding pharmacies.
|
|
|

.
Bloodspot™ Amino Acid Assay*
The Bloodspot Amino Acid Assay can illuminate problems in amino acid absorption by determining essential amino acid imbalances. The Bloodspot Amino Acid Assay is a non-invasive alternative to a blood draw in determining essential amino acid status and therefore may be a better alternative in the pediatric setting. The test kit is simple enough for the patient to use at home.
Bloodspot™ Amino Acid testing features:
- Amino acid testing from a simple finger stick
- Easy implementation in any practice
- Cost-effective testing and therapy
- Customized amino acid formulations based on your patient's specific test results
- An economical follow-up plasma amino acid testing to monitor therapy
*Bloodspot profile not available in New York
Metametrix amino acid testing features:
- A variety of specimen and profile choices
- Customized amino acid formulations based on your patient's specific results
|
|
Clinician Info
| Test name: |
0012 - Amino Acids - 40 analytes
|
|
|
| Description: |
The urine amino acid profile reports levels of essential amino acids and their derivatives in categories. Functional vitamin and mineral deficiencies and diagnosis of metabolic disorders, including neuroendocrine, muscle wasting, and bone loss, can be determined from a urine amino acid analysis. A 24-hour urine collection gives the most accurate analysis of urine amino acids.
|
|
|
| Method: |
ION Exchange HPLC |
|
|
| Turnaround time: |
7-14 days, 10 days average |
|
|
|
Analytes:
|
ESSENTIAL AMINO ACIDS
Arginine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Threonine Tryptophan Valine
ESSENTIAL AMINO ACID DERIVATIVES
NEUROENDOCRINE METABOLISM
Gamma-Aminobutyric Acid Glycine Serine Taurine Tyrosine
AMMONIA/ENERGY METABOLISM
Alpha-Aminoadipic Acid Asparagine Aspartic Acid Citrulline Glutamic Acid Glutamine Ornithine
SULFUR METABOLISM
Cystine Cystathionine Homocystine
ADDITIONAL METABOLITES
Alpha-Amino-N-Butyric Acid Alanine Anserine Beta-Alanine Beta-Aminoisobutyric Acid Carnosine Ethanolamine Hydroxylysine Hydroxyproline 1-Methylhistidine 3-Methylhistidine Phosphoethanolamine Phosphoserine Proline Sarcosine
|
|
CPT codes:
| 82139 |
- |
Amino acids, 6 or more, quantitative |
|
| |
|
|
Plasma and urinary amino acids and selected sulfur metabolites in young men fed a diet devoid of methionine and cystine.
Lakshmanan FL, Perera WD, Scrimshaw NS, Young VR. Am J Clin Nutr. 1976;29(12):1367-1371.
Comparison of uncertainties related to standardization of urine samples with volume and creatinine concentration.
Garde AH, Hansen AM, Kristiansen J, Knudsen LEAnn. Occup Hyg. Mar 2004;48(2):171-179.
Correlation between plasma and urine phenylalanine concentrations.
Boulos M, Boulat O, Van Melle G, Guignard JP, Matthieu JM. Biol Neonate. 2004;86(1):6-9.
Tyrosine and glutamic acid in plasma and urine of patients with altered thyroid function.
Belanger R, Chandramohan N, Misbin R, Rivlin RS. Metabolism. 1972;21(9):855-865.
Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition.
Kopple JD, Vinton NE, Laidlaw SA, Ament ME. Am J Clin Nutr. 1990;52(5):846-853.
High predictivity of galactosyl-hydroxylysine in urine as an indicator of bone metastases from breast cancer.
Moro L, Gazzarrini C, Modricky C, et al. Clin Chem. May 1990;36(5):772-774.
|
|