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Amino Acids 40 - Plasma

Amino Acids: The Body’s Fundamental Building Blocks

Amino acids make up proteins found in every tissue of the body. They play a major role in nearly every chemical process that affects both physical and mental function. As a result, amino acids have more diverse functions than any other nutrient group, including:
  • Cellular energy production
  • Formation of ligaments, tendons, and bones
  • Formation of antibodies
  • Formation and regulation of enzymes and blood transport proteins

Plasma Amino Acids

Fasting plasma levels represent a homeostatic balance between supply and utilization of amino acids. Problems in amino acid metabolism are revealed by the amino acids and metabolites that are reported in categories according to function.

Plasma 20 and 40 Profiles
The 20 Profile can illuminate problems in amino acid absorption by determining essential amino acids imbalances. Additionally, evaluation of essential amino acid derivatives show neuroendocrine metabolic disorders as well as functional vitamin and mineral deficiencies. The 40 Profile adds amino acid derviatives focusing on energy, sulfation, muscle wasting, and bone loss.

 

Customized Amino Acid Formula
A formula for a customized amino acid blend individually formulated, based on your patient’s specific test results, is provided with every plasma amino acid test result. These customized amino acid formulations provide appropriate amounts of essential and conditionally essential amino acids, delivered in a balanced ratio to offset the risk of imbalance sometimes seen with the use of single amino acid supplements. This blend can be made by many compounding pharmacies.

Urine Amino Acids

Urine amino acid analysis is better for discriminating the metabolic effects of short-term (24 to 48 hour) dietary changes than is plasma analysis. Conversely, urine analysis requires more rigorous dietary control than plasma analysis in order to give an accurate picture of a patient’s steady-state amino acid sufficiency and metabolism.

Urine 40 Profile
The urine amino acid profile reports levels of essential amino acids and their derivatives in categories. Functional vitamin and mineral deficiencies and diagnosis of metabolic disorders, including neuroendocrine, muscle wasting, and bone loss, can be determined from a urine amino acid analysis. A 24-hour urine collection gives the most accurate analysis of urine amino acids.

 

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Bloodspot™ Amino Acid Assay*

The Bloodspot Amino Acid Assay can illuminate problems in amino acid absorption by determining essential amino acid imbalances. The Bloodspot Amino Acid Assay is a non-invasive alternative to a blood draw in determining essential amino acid status and therefore may be a better alternative in the pediatric setting. The test kit is simple enough for the patient to use at home.

    Bloodspot™ Amino Acid testing features:

    Amino acid testing from a simple finger stick

    Easy implementation in any practice

    Cost-effective testing and therapy

    Customized amino acid formulations based on your patient's specific test results

    An economical follow-up plasma amino acid testing to monitor therapy

    *Bloodspot profile not available in New York

Clinician Info
Test name: 0010 - Amino Acids - 40 analytes
Description: Fasting plasma levels of amino acids represent homeostatic balance between supply and utilization of these critical building blocks. Problems in amino acid metabolism are revealed by the amino acids and metabolites that are reported in categories according to function. Amino acid analysis helps with determination of amino acid imbalances, evaluation of functional vitamin and mineral deficiencies, and diagnosis of metabolic disorders. A formula for a custom amino acid blend is provided with every plasma amino acid test result. This blend can be made by any compounding pharamacy.
Method: ION exchange HPLC
Turnaround time: 7-14 days, 10 days average
Analytes: ESSENTIAL AMINO ACIDS
Arginine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine


ESSENTIAL AMINO ACID DERIVATIVES


NEUROENDOCRINE METABOLISM
Gamma-Aminobutyric Acid
Glycine
Serine
Taurine
Tyrosine


AMMONIA/ENERGY METABOLISM
Alpha-Aminoadipic Acid
Asparagine
Aspartic Acid
Citrulline
Glutamic Acid
Glutamine
Ornithine


SULFUR METABOLISM
Cystine
Cystahionine
Homocystine


ADDITIONAL METABOLITES
Alpha-Amino-N-Butyric Acid
Alanine
Anserine
Beta-Alanine
Beta-Aminoisobutyric Acid
Carnosine
Ethanolamine
Hydroxylysine
1-Methylhistidine
3-Methylhistidine
Phosphoethanolamine
Phosphoserine
Proline
Sarcosine


CPT codes:

82139 - Amino acids, 6 or more, quantitative
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